You are viewing BNF. Administration of gonadorelin analogues produces an initial phase of stimulation; continued administration is followed by down-regulation of gonadotrophin-releasing hormone receptors, thereby reducing the release of gonadotrophins follicle stimulating hormone and luteinising hormone which in turn leads to inhibition of androgen and oestrogen production.

In endometriosis do not use for longer than 6 months do not repeat ; undiagnosed vaginal bleeding. History of depression ; patients with metabolic bone disease decrease in bone mineral density can occur. When used for breast cancer. When used for Prostate cancer. Anxiety ; asthenia ; depression ; diabetes mellitus ; dizziness ; dry mouth ; embolism ; gastrointestinal discomfort ; gynaecomastia ; haemorrhage ; headache ; hot flush ; hyperhidrosis ; hypersensitivity ; hypertension ; joint disorders ; menstrual cycle irregularities ; mood altered ; muscle complaints ; nausea ; oedema ; ovarian and fallopian tube disorders ; pain ; painful sexual intercourse ; pelvic pain ; sexual dysfunction ; skin reactions ; sleep disorders ; weight changes.

Alopecia ; appetite abnormal ; asthma exacerbated ; chills ; confusion ; constipation ; diarrhoea ; drowsiness ; dyspnoea ; flatulence ; gout ; muscle weakness ; taste altered ; testicular disorders ; tinnitus ; vertigo ; vision disorders ; vomiting.

Abnormal sensation in eye ; chest pain ; difficulty standing ; fever ; hypotension ; influenza like illness ; musculoskeletal stiffness ; nasopharyngitis ; orthopnoea ; osteoarthritis ; QT interval prolongation. Angioedema ; malaise. With intramuscular use. With subcutaneous use. During the initial stage increased production of testosterone may be associated with progression of prostate cancer. Non-hormonal, barrier methods of contraception should be used during entire treatment period.

Pregnancy should be excluded before treatment, the first injection should be given during menstruation or shortly afterwards or use barrier contraception for 1 month beforehand.

The advice is contingent upon the continuing availability of the patient access scheme in NHS Scotland or a list price that is equivalent or lower. Powder and solvent for suspension for injection. Other drugs classified as gonadotrophin-releasing hormones. History of depression ; patients with metabolic bone disease decrease in bone mineral density can occur When used for breast cancer risk factors for osteoporosis. General side-effects Common or very common Anxiety ; asthenia ; depression ; diabetes mellitus ; dizziness ; dry mouth ; embolism ; gastrointestinal discomfort ; gynaecomastia ; haemorrhage ; headache ; hot flush ; hyperhidrosis ; hypersensitivity ; hypertension ; joint disorders ; menstrual cycle irregularities ; mood altered ; muscle complaints ; nausea ; oedema ; ovarian and fallopian tube disorders ; pain ; painful sexual intercourse ; pelvic pain ; sexual dysfunction ; skin reactions ; sleep disorders ; weight changes.

Uncommon Alopecia ; appetite abnormal ; asthma exacerbated ; chills ; confusion ; constipation ; diarrhoea ; drowsiness ; dyspnoea ; flatulence ; gout ; muscle weakness ; taste altered ; testicular disorders ; tinnitus ; vertigo ; vision disorders ; vomiting. Rare or very rare Abnormal sensation in eye ; chest pain ; difficulty standing ; fever ; hypotension ; influenza like illness ; musculoskeletal stiffness ; nasopharyngitis ; orthopnoea ; osteoarthritis ; QT interval prolongation.

Frequency not known Angioedema ; malaise. Common or very common With intramuscular use bone disorders ; bone fracture ; breast abnormalities ; glucose tolerance impaired ; hyperglycaemia ; musculoskeletal disorder ; seborrhoea ; sensation abnormal ; urinary disorders ; vulvovaginal disorders With subcutaneous use dysuria ; vulvovaginal dryness.

Uncommon With intramuscular use broken nails ; central nervous system haemorrhage ; cerebral ischaemia ; concentration impaired ; cystocele ; dry eye ; fluid retention ; hirsutism ; hyperlipidaemia ; memory impairment ; myocardial ischaemia ; oral ulceration ; palpitations ; syncope ; thrombocytosis ; tremor With subcutaneous use paraesthesia. Frequency not known With subcutaneous use bone disorder ; breast pain ; memory loss.

Side-effects, further information During the initial stage increased production of testosterone may be associated with progression of prostate cancer. Rotate injection site to prevent atrophy and nodule formation. SMC www. Back to top.Medically reviewed by Drugs.

The Trelstar brand of triptorelin is used in men to treat the symptoms of prostate cancer. Trelstar treats only the symptoms of prostate cancer and does not treat the cancer itself. The Triptodur brand of triptorelin is used to treat precocious puberty in boys and girls who are at least 2 years old. Do not use if you are pregnant. Use effective birth controland tell your doctor if you become pregnant during treatment. Some people using triptorelin have had new or worsening mental problems or seizures convulsions.

Call your doctor right away if you have a seizure, or any unusual changes in mood or behavior anger, aggression, crying, feeling restless or irritable. Triptorelin can cause a temporary increase in certain hormones, especially when you first start using triptorelin. This may cause side effects that are similar to the condition being treated. You should not use this medication if you are allergic to triptorelin or similar drugs such as leuprolide LupronViadur, Eligard or goserelin Zoladex.

Do not use triptorelin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Triptorelin

Triptorelin is injected into a muscle. A healthcare provider can teach you how to properly use the medication by yourself. Triptorelin is usually given once every 4, 12, or 24 weeks. Your dose schedule will depend on the strength and brand of triptorelin you are using. Triptorelin must be mixed with a liquid diluent before using it.

When using injections by yourself, be sure you understand how to properly mix and store the medicine. Triptorelin can increase certain hormones when you first start using triptorelin or after each new injection. This may cause symptoms of prostate cancer or precocious puberty to get worse for a short time. These side effects should get better within 1 to 2 months.

Call your doctor if your symptoms do not improve, or if they get worse while using triptorelin. Each vial bottle is for one use only. Throw it away after one use, even if there is still medicine left inside.Triptorelinsold under the brand names Decapeptyl and Gonapeptyl among others, is a medication that acts as an agonist analog of Gonadotropin-releasing hormonethus reversibly repressing of luteinizing hormone LH and follicle-stimulating hormone FSH [1] [2].

Primary indications include endometriosis, for the reduction of fibroids, for prostatic cancer, and to treat male hypersexuality with severe sexual deviation. It was patented in and approved for medical use in Another common use in the United Kingdom is for hormone replacement therapy to suppress testosterone or estrogen levels in transgender people in conjunction with estradiol valerate for trans women or testosterone for trans men.

Spironolactone and cyproterone acetate are other drugs used by trans people to suppress sex hormones, but these drugs have a completely different mechanism of action. Triptorelin has been used as a chemical castration agent for reducing sexual urges in sex offenders.

This causes an initial phase of LH and FSH stimulation, prior to down-regulation of the gonadotrophin-releasing hormone receptors, thereby reducing the release of gonadotrophins in the long term, which in turn leads to the inhibition of androgen and oestrogen production. General side effects can include: [2]. Triptorelin should not be used for more than 6 months for endometriosis [2]and should be used with care in patients with metabolic bone disease and osteoporosis due to the risk of osteopenia.

Triptorelin is marketed under the brand names Decapeptyl Ipsen and Diphereline and Gonapeptyl Ferring Pharmaceuticals. In the United Statesit is sold by Watson Pharmaceuticals as Trelstar and by Arbor Pharmaceuticals as Triptodur an extended-release 6-month depot injection.

In Irantriptorelin is marketed under the brand name Variopeptyl. From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. Retrieved London: Pharmaceutical Press. Robin Analogue-based Drug Discovery. Retrieved 11 November Sexual and Relationship Therapy. GnRH and gonadotropins. Follicle-stimulating hormone Human chorionic gonadotropin Luteinizing hormone Menotropin Urofollitropin.

Sex steroid antagonists via disinhibition of the HPG axis : Antiandrogens e. GnRH and gonadotropin receptor modulators. Agonists: Peptides: Choriogonadotropin alfa Human chorionic gonadotropin Luteinizing hormone Lutropin alfa Menotropin human menopausal gonadotropin.Dal Prato, A. Borini, M. Trevisi, M. Bonu, E. Sereni, C. However, the minimal effective agonist dose remains to be determined.

The aim of the study was to investigate the effect of a reduced daily dose of triptorelin, administered at the start of ovarian stimulation, on the results of IVF and intracytoplasmic sperm injection.

Pituitary desensitization was obtained in group 1 66 patients with a single 3. No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.

The possibility of a shorter treatment protocol requiring lower amounts of gonadotrophins should be considered in view of its economic advantage. Over the last ten years, pre-treatment with gonadotrophin-releasing hormone GnRH agonists in women undergoing controlled ovarian hyperstimulation COH for assisted reproduction has became very common in almost all IVF centres.

The suppression of pituitary gonadotrophin secretion before and during induction of multiple follicular growth has some benefits, including: i prevention of premature luteinizing hormone LH surge and luteinization, resulting in a lower cancellation rate; ii improvement in follicular recruitment with a larger number of oocytes recovered both in normal and poor responders; iii improvement in routine organization of assisted reproduction Zorn et al.

The widespread use of long-acting GnRH agonist formulations has increased patients' and clinicians' convenience. However, it has been suggested that complete pituitary desensitization achieved by long-term use of GnRH agonist has the disadvantages of inducing slower and lower ovarian response especially in low responders compared with gonadotrophins alone, requires a higher number of gonadotrophin ampoules Ben-Rafael et al.

What is more, GnRH agonist has been shown to have a direct effect on ovarian steroidogenesis Casper and Yen, ; Tureck et al. Several authors have suggested that partial pituitary desensitization in an assisted reproduction procedure might be sufficient Balasch et al. Some authors Broekmans et al. A recent report Janssens et al.

triptorelin ivf

It has been demonstrated that once the pituitary is suppressed, the dose of GnRH agonist needed to prevent an LH surge decreases with the length of treatment Sandow and Donnez, Lowering the dose of triptorelin at the start of stimulation from 0. Feldberg et al.Decapeptyl triptorelin is a gonadotropin-releasing hormone GnRH agonist analogue drug.

It is used in assisted reproduction treatments to control ovarian function in in vitro fertilization IVF cycles. The active principle of Decapeptyl is triptorelin and its excipients are: mannitol in the vial and sodium chloride and water for preparations to be injected into the vial. Tryptorelin is an agonist analogue of GnRH. The main function of GnRH in the body is to promote or increase the release of follicle-stimulating hormone FSH and luteinizing hormone LHwhich are the gonadotropins involved in follicular development.

Once this first phase has passed, due to a decrease in sensitivity to this medication, the release of these hormones is inhibited. The role of tryptorelin is to allow control of the function of the ovaries in ovarian stimulation cycles. It inhibits the LH peak that causes ovulation and thus prevents spontaneous ovulation.

If this were to occur, it would cause the cycle to be cancelled because it would not be possible to obtain the eggs for fertilization in the laboratory. In addition, it also allows monitoring of ovarian activity in patients with ovarian function who undergo frozen embryo transfers or egg donation cycles.

This allows the endometrium to be in optimal conditions for embryo implantation. In assisted reproduction treatments, both daily and monthly Decapeptyl are used. Depending on which protocol is carried out, one or the other will be administered.

Decapeptyl is indicated to treat female sterility, as a complementary treatment to gonadotropins HMG, FSH, hCG during ovulation stimulation in assisted reproduction treatments.

It is also used in patients with ovarian function who undergo embryo transfer in egg donation or frozen embryo cycles. Monthly Decapeptyl is also indicated in other pathologies, such as for the treatment of endometriosisuterine fibroidsearly puberty and prostate cancer.

However, quarterly and semi-annual presentations are only indicated in patients with prostate cancer. The route of administration of daily Decapeptyl is subcutaneousin the tissue located immediately under the skin. The rest of the presentations require intramuscular administration, directly into the muscle. The main difference between both types of administration is the depth at which the injection is performed, being deeper the intramuscular one, which is usually performed in the buttocks or in the arm.

Because intramuscular injection is recommended to be performed by health care personnel, this article will focus on the subcutaneous administration of daily Decapeptyl, which is usually self-injected into the abdominal area.

For the injection, in addition to the drug, it will be necessary to have a syringe, an intramuscular injection needle, a subcutaneous injection needle, gauze and alcohol. The first step will be to reconstitute the drug before injecting it. To do this, the following steps must be taken:.All products on this site are for In-Vitro Research, Development use only.

Products are Not for Human consumption of any kind. You may be asking the question of what is triptorelin used for. Well, the answer is Triptorelin is a hormone therapy medication used to treat various conditions including early onset of puberty in boys and girls, fertilization treatment, and prostate cancer. Triptorelin is classed as a research peptide and is still being studied. In brief, it is a man-made substance that has shown effective on various health issues and especially in treating prostate cancer.

Cancer of the prostate requires hormone testosterone to develop. Nearly all testosterone in men is produced by the testicles. But a tiny amount is formed in the adrenal glands that are situated over the kidneys. Triptorelin halts the making of testosterone from the testicles. It reduces the levels of testosterone and therefore can lower or prevent cancer of the prostate. The research peptide Triptorelin is prescribed either on its own or with other medicines to treat prostate cancer.

It can also be used before or after radiation therapy and surgery. In addition, it is used to manage prostate cancer that has spread to other areas of the body. Triptorelin is not a cure for prostate cancer but is used as a treatment. It acts at an adenohypophyseal level, stimulating the synthesis and release of gonadotropins LH luteinizing hormone and FSH follicle-stimulating hormone. The increase in gonadotropin levels causes an increase in the production of testosterone in the testis or estrogens in the ovary, which in turn inhibits the hypothalamic production of GnRH, by negative feed-back, feeding back the hypothalamic-pituitary-gonadal axis.

Sufferers with advanced prostate cancer sometimes have alternating triptorelin therapy.

triptorelin ivf

This means it is given for a few months until the cancer level is reduced, and this is monitored by PSA blood tests.

Then a break from triptorelin treatment is given until it is necessary to start again. The treatment involves a Triptorelin Injection administered monthly or every months with a longer-acting preparation into the buttock known as intramuscular, or under the skin subcutaneously. With all research peptides, there might be side effects. Some people find the injection unpleasant, so anesthetic cream is applied beforehand. Osteoporosis can develop with long term use of Triptorelin.

It should not be used whilst pregnant. Plus if you have any other underlying health condition it is important to inform your doctor. Other common problems logged from a study with triptorelin are bone pain, cold or flu, depression, diarrhea, headache, hot flashes, impotence, nausea, sickness, and vaginal bleeding.

Hormones are naturally made in the body for it to work effectively. They work as chemical messengers and control the workings of cells and organs. Hormone therapy like triptorelin obstructs the way hormones are made and the way they work.

What Is Decapeptyl Injection Used For in IVF?

As we mentioned early on triptorelin can also help treat early puberty in children and help with infertility problems. In the UK triptorelin is used as a hormonal treatment in transgender people to repress testosterone and estrogen synthesis. Plus it has been found to be effective in treating hormone-receptor-positive breast cancer.

It is amazing at what research peptides can do these days to help treat various conditions and diseases. For those searching for the research chemical triptorelin check out USA Peptides now.

Blog Search Search for:.The depot shot. First off, what is a depot shot? Most depot shots contain the active ingredient leuprolide acetate. Others use a similar synthetic hormone that does the same thing: suppress the hormone signal from the pituitary gland to the ovaries. Depot shots are used in the treatment of endometriosis, uterine fibroids and, interestingly, prostate cancer.

Different countries have different drug names. In either 3mg or 3.

triptorelin ivf

Premature ovarian failure means no depot shot is needed. The depot shot plays a crucial role in synchronising donor and recipient cycles. Side effects include mood swings, hot flushes, headaches, nausea, depression and, sometimes, menstrual-like bleeding.

But many egg recipients report no side effects. When to take the depot shot? Your consultant will advise. Most depot shots are administered on the second or third day of the penultimate bleed before egg retrieval.

The latter makes the lining as accommodating as a luxury mattress from Harrods. That bleed can be helped along by a course of monophasic birth-control pills that typically stop three days after the depot shot. You start taking your estrogen pills soon after the start of the bleed. Just follow your treatment protocol. Depot shots for fertility treatments are usually given intra-muscularly into the upper-outer quadrant of your buttock.

Use a healthcare professional. It worked for us. We had successful donor-egg treatment and now have our precious daughter. Good luck with your treatment. Many thanks for the incredibly informative article.

Hello, I had my shot, but have not gotten my last bleed yet. I got my shot 10 days ago. Do I have to start bleeding or it is okay not to start that last bleed. Thank you. Hi, I am in the same situation, 10 days today and no bleeding.

triptorelin ivf

How long it takes for your bleed come? Your comment. Call us on Depot shot: a guide for donor-egg patients The depot shot. Thank you for this article — it was incredibly helpful and informative. Follow Us Facebook. Sitemap Website Terms of Use. Spread the word! Share this page with your friends.


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